September 13, 2022

Welcome to the September session!

We are excited to host two great talks this month:

Telomeres and the control of cell proliferation

Teresa Teixera, PhD

CNRS, France

Highways for heterochromatin repair

Irene Chiolo, PhD

USC, USA

About the speaker: Teresa Teixera

Teresa Teixera

Maria Teresa Teixeira is Director of Research at the French National Centre for Scientific Research (CNRS), group leader and head of the Laboratory of Molecular and Cellular Biology of Eukaryotes at the Institute of Physical and Chemical Biology in Paris. Dr. Teixeira obtained her PhD at the University of Paris-Saclay in 2000 for her work at Pasteur Institute under the supervision of Bernard Dujon. She then moved to ISREC in Lausanne to join Joachim Lingner’s lab and obtained a permanent position in CNRS in 2005. First appointed in Lyon, she established her group in Paris in 2010. Maria Teresa Teixeira’s current main focus is the study of telomere shortening mechanisms and their consequences for cell proliferation ability, namely, the control of replicative senescence, using Saccharomyces cerevisiae as model organism. She has provided evidence for the first telomere reaching a critical short length being the major determinant of the onset of senescence in budding yeast. Her team also focused on the mechanism of telomere shortening in the absence of telomerase and contributed to the elucidation of the DNA-end replication problem. More recently, she developed microfluidics devices to assess replicative senescence in single-cell lineages from telomerase inactivation to cell death. This approach revealed a cryptic route to senescence prone to genomic instability. Mathematical modelling of senescence revealed components of cell-to-cell variability in senescence and showed how intrinsic properties of telomere replication contribute to generate phenotypic variants. Maria Teresa Teixeira received an ERC starting Grant and a EMBO Young Investigator award.

About the speaker: Irene Chiolo

Irene Chiolo

Irene Chiolo is Associate Professor of Biological Sciences at the Department of Molecular and Computational Biology, University of Southern California (USC). Dr. Chiolo obtained her PhD at the Milano University for her work done at the IFOM institute under the supervision of Marco Foiani. She then moved to the Lawrence Berkeley National Laboratory to join Gary H. Karpen’s lab and, from 2013, she took a position as assistant and then associate professor at the USC. Dr. Chiolo research interests are in nuclear architecture and dynamics, DNA repair, homologous recombination, and chromatin organization. Currently, the lab focuses on understanding DNA double-strand break (DSB) repair pathways in heterochromatin, which mostly comprises repetitive DNA sequences prone to aberrant recombination. Her studies at the forefront of this field have yielded major breakthroughs over the past several years, representing a concrete and necessary step toward understanding aging, neurodegenerative diseases, cancer and other genome-instability disorders. Since she established her lab at USC in 2013, her group has discovered essential roles of nuclear architecture and dynamics in heterochromatin repair, establishing a new framework for understanding the causes of cancer and other genome instability disorders.

About GiiN webinar series

The first GiiN Webinars Series (2021-2022) happens every second Tuesday of the month. It covers latest cutting-edge research in the field of genome stability from two scientists working either in the Italian territory or abroad. This series operates under the kind patronage of AIRC Italian Foundation for Cancer Research.

For more information, to volunteer or to be added to our mailing list, contact us at genomeintegrityitaly@gmail.com